Anti Depression Guide

The medical fraternity often claims that a major cause of depression, anxiety, and other forms of emotional disorders, is chemical imbalance. However, there is seldom any discussion about what causes the chemical imbalance. I have been searching for answers to this question and so far I have found that there is very little information provided by doctors, scientists, or clinical researchers.

There is a considerable amount of information discussing what the chemical imbalances are and what can be done, medically, to adjust the imbalance of chemicals. However, despite a lot of research over a long period of time, it appears that there are only several theories put forward regarding possible causes. One of these relates to a sustained increase in the production of adrenalin as a result of daily stressors, and a corresponding and compensating reduction in the production of the neurochemicals [or neurotransmitters] such as seratonin and cortisol.

Another theory suggests that disturbed sleep patterns and/or chronic pain cause seratonin to be used quicker than it can be replaced by the body. This leads to a situation where the synapses [the region where two or more nerve cells meet and across which an impulse passes] have insufficient amounts of neurotransmitter in them to allow the passage of complete signals relating to sleep, pain control, and mood control. This, in turn, often results in a snowball effect that compounds the problem.

There are some cynical people out there who believe that pharmaceutical companies may know more about the causes of the imbalances than they are prepared to divulge because it may lead to a downturn in the lucrative sales of their products. Perhaps the tobacco industry’s record caused them to have this slant on their outlook? They may have a point though as I understand that not all sufferers of depression and anxiety etc. have a chemical imbalance; many people do not respond to antidepressants used to compensate for chemical imbalances; and there are times when sufferers respond positively to placebos. In other circumstances it is time that tends to heal the problem.

I believe that the medical profession really is trying to get a much better understanding of the problem. viz:-

“A study at Baylor College of Medicine in Houston may lead to a better understanding of how antidepressants like Prozac work — and how to make them more effective.” 2005

“Howard Hughes Medical Institute investigator Eric Gouaux at Oregon Health and Science University (OHSU) and colleagues Satinder K. Singh and Atsuko Yamashita published their findings August 8, 2007, in an advance online publication in the journal Nature. ….. The researchers began their studies with the goal of understanding how TCAs interact with their clinical target, sodium-coupled neurotransmitter transporters. These transporters mop up neurotransmitters from the synapse, the junction between neurons. Neurotransmitters are molecules that neurons use to communicate with neighbouring neurons. TCAs work by inhibiting the reuptake of neurotransmitters by neurons.

Disorders such as depression, epilepsy, autism, or obsessive-compulsive disorder can result from impaired function of sodium-coupled neurotransmitter transporters. Thus, these molecules are the target of a variety of drugs, including TCAs.

It has been a great challenge, however, to understand precisely how these molecules function and interact with drugs. The problem, Gouaux said, is that the transporters found in humans are not amenable to study.”

Another person has remarked that life would be miserable if we did not have some chemical imbalances that affect our moods. When you think about this there is some merit to the statement. Without mood swings, ostensibly brought about by chemical imbalances, we would all be like the legendary Zombies, or living dead. We would not enjoy the natural highs of endorphin, the body’s opiate-like hormone, brought about by singing, dancing and exercise. Nor would we be able to display sorrow or grief when it is appropriate to do so. And if we did not have our down days we would not have a yardstick to measure against and appreciate the good days.

We are all probably aware that it is our thoughts that generally prompt the secretion of the various hormones. If we think that our safety is being threatened, we quickly secrete adrenalin and its cohorts to equip us for fight or flight by closing down nutrient supply to some organs, such as the digestive system, and re-directing the nutrients to the muscles, heart and lungs until the threat is gone and our system can return to normal.

When we anticipate [think] something favorable is about to happen, we produce hormones that put us in a good mood; and thinking of a sumptuous meal causes us to salivate in anticipation of partaking the meal.

This, together with my personal experiences, convinces me that, if our thoughts influence our body’s endocrine glands [those that excrete the hormones and saliva etc.] then, by controlling our thoughts we can influence the secretions of hormones, and the timing of such secretions, to our advantage. Cognitive behavioral therapy [CBT] is a relatively new method of treating problems associated with depression and anxiety etc. and is certainly a step in the right direction. This, and other forms of mental programming, will be the subject of much of my discussion in future.

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